RNA Details
Disease Name
cystic fibrosis
Tissue
lung
RNA Symbol
miR-199a-5p
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
In vivo experiment and BAL fluid collection and analysis; qRT-PCR; etc.
Target
Cav1
Pathway
AKT/MIR-199A-5P/CAV1 signaling pathway
PubMed ID
Title
Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation
Year
2015
Function
"In CF macrophage, activated PI3K/AKT pathway increase miR-199a-3p expression, reduce expression of CAV1, leading to increased TLR4 signaling and inflammation. Celecoxib re-establishes the AKT/miR-199a-5p/CAV1 axis in CF macrophages, and ameliorates lung hyper-inflammation in Cftr-deficient mice."